Trying to reach Vegas before the hitchhiker can go to the police, Gonzo gives Duke part of a sheet of Sunshine Acid, then informs him that there is little chance of making it before the drug kicks in.
By the time they reach the strip, Duke is in the full throes of his trip, and barely makes it through the check-in, all the while hallucinating that the hotel clerk is a moray eel, and that his fellow bar patrons are lizards in the depths of an orgy.
Their trips mostly over, Gonzo deals with Lucy over the phone (pretending that he is being savagely beaten by thugs), as Duke attempts to mellow out by trying some of Gonzo's stash of adrenochrome.
However, the trip spirals out of control, and Duke is reduced to an incoherent mess before he blacks out.
Sensing the trouble this could get them into, Duke convinces Gonzo to ditch Lucy in another hotel before her trip wears off. A.'s convention, and the pair discreetly snort cocaine as the guest speaker delivers a comically out-of-touch speech about "marijuana addicts" before showing a brief film.